Although animal experiments have shed some light on viral and host factors that contribute to nipah virus pathogenicity, nipah virus pathogenesis is currently poorly understood. despite this lack of understanding of how nipah virus causes disease, antiviral treatments are being developed, with promising results.. Hendra and nipah viruses: pathogenesis, animal models and recent breakthroughs in vaccination hana m weingartl national centre for foreign animal disease, canadian food inspection agency, winnipeg, mb, canada abstract: hendra and nipah viruses are two highly pathogenic zoonotic members of the genus henipavirus, family paramyxoviridae, requiring work under biosafety level 4 conditions due to a. Animal models of disease shed light on nipah virus pathogenesis and transmission. emmie de wit, in this review we discuss the current state of knowledge on the pathogenesis and transmission of nipah virus, focusing on dissemination of the virus through its host, known determinants of pathogenicity and routes of zoonotic and human-to-human.
Since data from human cases are sparse, this knowledge is largely based on the results of studies performed in animal models that recapitulate nipah virus disease in humans. published 2014. this article is a u.s. government work and is in the public domain in the usa.. Animal models of disease shed light on nipah virus pathogenesis and transmission: nipah virus pathogenesis and transmission. the journal of pathology, 235, 196 � 205. doi: 10.1002/path.4444, , [web of science
